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Enhancement of spontaneous C3H/HeJ mammary tumorigenesis by long-term polyadenylic-polyuridylic acid therapy.

Abstract
Female C3H/HeJ mice received weekly s.c. injections of 2 mg polyadenylic-polyuridylic acid. Therapy was initiated at either 2 or 9 months of age. In both cases, poly-adenylic-polyuridylic acid-treated animals developed the spontaneous mammary carcinoma associated with this strain more rapidly. Because the opposite result was formerly observed for AKR spontaneous leukemia, the data indicate the polyadenylic-polyuridylic acid has no generalized antineoplastic effect upon spontaneous tumors genetically associated with specific murine strains.
AuthorsW P Drake, W J Pendergrast Jr, R E Kramer, M R Mardiney Jr
JournalCancer research (Cancer Res) Vol. 35 Issue 11 Pt 1 Pg. 3051-3 (Nov 1975) ISSN: 0008-5472 [Print] United States
PMID1182699 (Publication Type: Journal Article)
Chemical References
  • Poly A-U
Topics
  • Animals
  • Female
  • Injections, Subcutaneous
  • Mammary Neoplasms, Experimental (chemically induced)
  • Mice
  • Mice, Inbred C3H
  • Poly A-U (administration & dosage)
  • Stimulation, Chemical
  • Time Factors

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