[Nitrullin -- a new original Russian drug of the nitrosomethylurea group].

Abstract

Hematologic thrombopenia and leukopenia formation limits use of nitrullin as a toxic hazard. The drug showed moderate effect in treating inoperable non-small cell cancer of the lung and satisfactory end results. The treatment had marked symptomatic effect in patients with this cancer and, as a consequence, improved the quality of life. Nutrullin had immuno-modulating effect. Its application alone or in combination with VPN showed good results in the management of small-cell cancer of the lung.

• Authors: V A Gorbunova, N F Orel, O V Semina, N S Besova, Z G Kadagidze
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 47 Issue 6 Pg. 680-3 ( 2001) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Nitrullin -- novyĭ original'nyĭ otechestvennyĭ preparat iz gruppy nitrozomocheviny.
• PMID: 11826488 (Publication Type: Clinical Trial, Clinical Trial, Phase II, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Antineoplastic Agents
• Nitrosourea Compounds
• nitrullin
• Citrulline

Topics

• Adenocarcinoma (drug therapy, mortality)
• Adult
• Aged
• Antineoplastic Agents (adverse effects, therapeutic use)
• Carcinoma, Non-Small-Cell Lung (drug therapy, mortality)
• Carcinoma, Small Cell (drug therapy, mortality)
• Carcinoma, Squamous Cell (drug therapy, mortality)
• Citrulline (adverse effects, analogs & derivatives, therapeutic use)
• Humans
• Lung Neoplasms (drug therapy, mortality)
• Lymphatic Metastasis
• Middle Aged
• Neoplasm Metastasis
• Nitrosourea Compounds (adverse effects, therapeutic use)
• Time Factors