Metabolism of kalopanaxsaponin K by human intestinal bacteria and antirheumatoid arthritis activity of their metabolites.

Abstract

When kalopanaxsaponin K (KPK) from Kalopanax pictus was incubated for 24 h at 37 degrees C with human intestinal microflora, KPK was mainly metabolized to kalopanaxsaponin I (KPI) via kalopanaxsaponin H (KPH) rather than via kalopanaxsaponin J (KPJ), and then transformed to kalopanaxsaponin A (KPA) and hederagenin. Bacteroides sp., and Bifidobacterium sp. and Fusobacterium sp. transformed KPK to KPI and KPA and hederagenin via KPH or KPJ. However, Lactobacillus sp. and Streptococcus sp. transformed KPK to KPI, KPA, and hederagenin only via KPJ. The metabolite KPA of KPK showed potent antirheumatoid arthritis activity.

• Authors: Dong-Hyun Kim, Eun-Ah Bae, Myung Joo Han, Hee-Juhn Park, Jong-Won Choi
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 25 Issue 1 Pg. 68-71 (Jan 2002) ISSN: 0918-6158 [Print] Japan
• PMID: 11824560 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antirheumatic Agents
• Oligosaccharides
• kalopanaxsaponin K
• Freund's Adjuvant

Topics

• Animals
• Antirheumatic Agents (metabolism, pharmacology)
• Arthritis, Experimental (drug therapy)
• Arthritis, Rheumatoid (drug therapy)
• Bacteria (metabolism)
• Capillary Permeability (drug effects)
• Chromatography, Thin Layer
• Edema (chemically induced, prevention & control)
• Feces (chemistry)
• Freund's Adjuvant
• Humans
• Intestinal Mucosa (metabolism)
• Magnetic Resonance Spectroscopy
• Male
• Mice
• Mice, Inbred ICR
• Oligosaccharides (metabolism, pharmacology)
• Plant Epidermis (chemistry)
• Rats
• Rats, Sprague-Dawley