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Vaticanol C, a novel resveratrol tetramer, inhibits cell growth through induction of apoptosis in colon cancer cell lines.

Abstract
A novel resveratrol tetramer, vaticanol C, isolated from the stem bark of Vatica rassak markedly suppressed cell growth through induction of apoptosis, which was characterized by nuclear changes and DNA ladder formation, in three different human colon cancer cell lines.
AuthorsTetsuro Ito, Yukihiro Akao, Toshiyuki Tanaka, Munekazu Iinuma, Yoshinori Nozawa
JournalBiological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 25 Issue 1 Pg. 147-8 (Jan 2002) ISSN: 0918-6158 [Print] Japan
PMID11824549 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • DNA, Neoplasm
  • Stilbenes
  • vaticanol C
  • Resveratrol
Topics
  • Antineoplastic Agents, Phytogenic (pharmacology)
  • Apoptosis (drug effects)
  • Colonic Neoplasms (drug therapy)
  • DNA, Neoplasm (drug effects)
  • Humans
  • Molecular Weight
  • Plant Epidermis (chemistry)
  • Resveratrol
  • Stilbenes (pharmacology)
  • Tumor Cells, Cultured

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