High serum concentrations of dimeric inhibins A and B in normal newborn girls.

Abstract

OBJECTIVE:

To establish the serum pattern of dimeric inhibins in normal girls during the newborn period and to examine its relationship with the postnatal gonadotropic surge.

DESIGN:

Retrospective study. SETTING; Division of endocrinology of a children's hospital.

PATIENT(S):

Thirty-one girls 4 to 65 days of age.

MAIN OUTCOME MEASURE(S):

Serum levels of FSH, LH, and inhibin A and B.

RESULT(S):

High serum concentrations of both dimeric inhibins were detected during the first weeks of life. Concentrations tended to decrease through the second month of age. Inhibin A and B concentrations positively correlated with age only during the first 2 weeks of life (r =.57, P<.05 and r =.70, P<.01, respectively). Inhibin A and B were positively and significantly correlated with LH (r =.57, P<.05 and r =.52, P<.05, respectively) and with each other (r =.68, P<.0001). No correlation was found between dimeric inhibins and FSH.

CONCLUSION(S):

The high inhibin concentrations observed in newborn girls, which indicate advanced follicular development and granulosa cell differentiation, may be useful markers for congenital gonadal disorders.

• Authors: Ignacio Bergadá, Gabriela M Ballerini, Sandra Ayuso, Nigel P Groome, César Bergadá, Stella Campo
• Journal: Fertility and sterility (Fertil Steril) Vol. 77 Issue 2 Pg. 363-5 (Feb 2002) ISSN: 0015-0282 [Print] United States
• PMID: 11821098 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• inhibin A
• inhibin B
• Inhibins
• Luteinizing Hormone
• Follicle Stimulating Hormone

Topics

• Enzyme-Linked Immunosorbent Assay
• Female
• Fluoroimmunoassay
• Follicle Stimulating Hormone (blood)
• Humans
• Infant
• Infant, Newborn (blood)
• Inhibins (blood)
• Luteinizing Hormone (blood)
• Retrospective Studies
• Statistics, Nonparametric