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Efficacy and safety of recombinant human follicle-stimulating hormone in men with isolated hypogonadotropic hypogonadism.

AbstractOBJECTIVE:
To assess the efficacy and safety of recombinant human follicle-stimulating hormone (rhFSH; follitropin alpha) in increasing sperm concentration in 26 men with severe isolated hypogonadotropic hypogonadism (IHH).
DESIGN:
Clinical and endocrine studies using an open design.
SETTING:
Six university clinical sites in three European countries.
PATIENT(S):
Azoospermatic patients aged 16 to 48 years with IHH.
INTERVENTION(S):
Patients received hCG for up to 6 months before 18 months of treatment with rhFSH. Sperm count, motility, and morphology were assessed every 3 months.
MAIN OUTCOME MEASURE(S):
Achievement of a sperm concentration of 1.5 x 10(6)/mL.
RESULT(S):
Spermatogenesis was achieved in 15 of 19 patients who could be evaluated, 12 achieving a sperm concentration of > or =1.5 x 10(6)/mL.
CONCLUSION(S):
With hCG, rhFSH is effective in initiating spermatogenesis in patients with IHH, and is well tolerated.
AuthorsPierre Bouloux, David W Warne, Ernest Loumaye, FSH Study Group in Men's Infertility
JournalFertility and sterility (Fertil Steril) Vol. 77 Issue 2 Pg. 270-3 (Feb 2002) ISSN: 0015-0282 [Print] United States
PMID11821082 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Chemical References
  • Chorionic Gonadotropin
  • Recombinant Proteins
  • Testosterone
  • Estradiol
  • Inhibins
  • Follicle Stimulating Hormone
Topics
  • Adolescent
  • Adult
  • Chorionic Gonadotropin (administration & dosage, therapeutic use)
  • Estradiol (blood)
  • Female
  • Follicle Stimulating Hormone (adverse effects, therapeutic use)
  • Humans
  • Hypogonadism (drug therapy, physiopathology)
  • Inhibins (blood)
  • Male
  • Middle Aged
  • Oligospermia (drug therapy, physiopathology)
  • Pregnancy
  • Recombinant Proteins (adverse effects, therapeutic use)
  • Sperm Count
  • Sperm Motility (drug effects)
  • Spermatogenesis (drug effects, physiology)
  • Testosterone (blood)

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