Abstract | OBJECTIVE: DESIGN: Clinical and endocrine studies using an open design. SETTING: Six university clinical sites in three European countries. PATIENT(S): Azoospermatic patients aged 16 to 48 years with IHH. INTERVENTION(S): Patients received hCG for up to 6 months before 18 months of treatment with rhFSH. Sperm count, motility, and morphology were assessed every 3 months. MAIN OUTCOME MEASURE(S): Achievement of a sperm concentration of 1.5 x 10(6)/mL. RESULT(S): Spermatogenesis was achieved in 15 of 19 patients who could be evaluated, 12 achieving a sperm concentration of > or =1.5 x 10(6)/mL. CONCLUSION(S): With hCG, rhFSH is effective in initiating spermatogenesis in patients with IHH, and is well tolerated.
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Authors | Pierre Bouloux, David W Warne, Ernest Loumaye, FSH Study Group in Men's Infertility |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 77
Issue 2
Pg. 270-3
(Feb 2002)
ISSN: 0015-0282 [Print] United States |
PMID | 11821082
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chorionic Gonadotropin
- Recombinant Proteins
- Testosterone
- Estradiol
- Inhibins
- Follicle Stimulating Hormone
|
Topics |
- Adolescent
- Adult
- Chorionic Gonadotropin
(administration & dosage, therapeutic use)
- Estradiol
(blood)
- Female
- Follicle Stimulating Hormone
(adverse effects, therapeutic use)
- Humans
- Hypogonadism
(drug therapy, physiopathology)
- Inhibins
(blood)
- Male
- Middle Aged
- Oligospermia
(drug therapy, physiopathology)
- Pregnancy
- Recombinant Proteins
(adverse effects, therapeutic use)
- Sperm Count
- Sperm Motility
(drug effects)
- Spermatogenesis
(drug effects, physiology)
- Testosterone
(blood)
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