| Abstract | INTRODUCTION: Acquired factor V inhibitor is rare and clinical symptoms are quite variable. Bleeding is the leading symptom but some patients are asymptomatic. Several diseases or conditions are associated with factor V inhibitors. Various treatments have been attempted but randomized or prospective trials are not available. EXEGESIS: Here we report three cases of acquired factor V inhibitor. These reports highlight the clinical variability of this disorder. Pathogenesis and therapy with reference to the literature are discussed. CONCLUSION: Factor V inhibitors are rare and associated to several diseases or conditions. Pathogenesis is still unclear except in patients exposed to bovine thrombin. The majority of the cases developed after surgery. In a few cases there is an association to a malignant or autoimmune disease. Plasmapheresis and platelet transfusions might be the best treatment in case of severe bleeding. High-dose intravenous immunoglobulin infusions have been used successfully in some cases and we report here their efficacy in two cases. |
| Authors | N Schleinitz, V Veit, D Chouquet, V Seux, D Arnoux, D Mokart, B Lelong, M C Alessi, G Kaplanski, J R Harlé
(Affiliation: Service de médecine interne, hôpital de la Conception, 13385 Marseille, France. nschleinitz at mail.ap-hm.fr)
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| Journal | La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne
(Rev Med Interne)
Vol. 22
Issue 11
Pg. 1119-23
(Nov 2001)
ISSN: 0248-8663 France |
| Vernacular Title | Anticoagulant acquis antifacteur V: nosologie, risque hémorragique et prise en charge thérapeutique à propos de trois observations. |
| PMID | 11817124
(Publication Type: Case Reports, English Abstract, Journal Article)
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| Chemical References |
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| Topics |
- Aged
- Blood Coagulation Disorders
(etiology)
- Factor V
(antagonists & inhibitors)
- Female
- Hemorrhage
(etiology, prevention & control)
- Humans
- Male
- Middle Aged
- Postoperative Complications
- Risk Factors
|
