| Abstract | A patient with end stage renal disease secondary to systemic lupus erythematosus (SLE) ultimately required amputation of the four extremities and developed mesenteric ischemia. The patient presented with widespread medial calcification involving various small to medium sized arteries, although no noticeable secondary hyperparathyroidism was observed. We speculated that SLE associated with systemic vasculitis and uremic milieu over a number of years may represent the perfect preexisting condition for calcific arteriolopathy to occur following which several factors including chronic administration of corticosteroids, photosensitivity in lupus, and significant weight loss may have contributed to acral gangrene and mesenteric ischemia. |
| Authors | N Igaki, R Moriguchi, Y Hirota, M Sakai, H Akiyama, F Tamada, M Oimomi, T Goto
(Affiliation: Department of Internal Medicine, Takasago Municipal Hospital.)
|
| Journal | Internal medicine (Tokyo, Japan)
(Intern Med)
Vol. 40
Issue 12
Pg. 1232-7
(Dec 2001)
ISSN: 0918-2918 Japan |
| PMID | 11813850
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Anti-Inflammatory Agents
- Parathyroid Hormone
- Steroids
- Calcium
- Phosphorus
|
| Topics |
- Amputation
- Angiography
- Anti-Inflammatory Agents
(adverse effects, therapeutic use)
- Arterial Occlusive Diseases
(blood, complications, etiology)
- Calciphylaxis
(blood, etiology, surgery)
- Calcium
(blood)
- Female
- Fingers
(blood supply)
- Gangrene
(blood, etiology, surgery)
- Humans
- Ischemia
(blood, complications, etiology)
- Kidney Failure, Chronic
(blood, etiology)
- Lupus Erythematosus, Systemic
(blood, complications, drug therapy)
- Magnetic Resonance Imaging
- Middle Aged
- Parathyroid Hormone
(blood)
- Phosphorus
(blood)
- Splanchnic Circulation
- Steroids
- Toes
(blood supply)
- Tomography, Emission-Computed, Single-Photon
|
