Production of respiratory tract tumors in hamsters by benzo(a)pyrene.

Abstract

Respiratory tumor induction was tested for the tumorigenic activity of benzo[a]pyrene alone. A group of 32 male and 28 female Syrian golden hamsters were given weekly intratracheal instillation of 1 mg of benzo[a]pyrene suspended in isotonic saline, for 30 weeks. Squamous cell carcinoma, adenocarcinoma, anaplastic carcinoma, adenoma, papilloma, and polyps were induced in the respiratory tract of hamsters. Tumor incidences were 42.3% in males and 57.7% in females. Respiratory carcinomas were inducible in hamsters by simple instillation of a low dose of benzo[a]pyrene without using a surface-active agent or carrier-dust. These findings may be useful as a standard data for cocarcinogenesis studies when using other modality combined with benzo[a]pyrene in experimental studies.

• Authors: N Kobayashi
• Journal: Gan (Gan) Vol. 66 Issue 3 Pg. 311-5 (Jun 1975) ISSN: 0016-450X [Print] Japan
• PMID: 1181231 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Benzopyrenes

Topics

• Adenocarcinoma (chemically induced)
• Animals
• Benzopyrenes
• Carcinoma, Squamous Cell (chemically induced)
• Cricetinae
• Female
• Male
• Papilloma (chemically induced)
• Polyps (chemically induced)
• Respiratory Tract Neoplasms (chemically induced)