Abietic acid inhibits lipoxygenase activity.

Abstract

In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC(50) of 29.5 +/- 1.29 microM was determined. Since the lipoxygenase pathway leads to the biosynthesis of leukotrienes this result supports the view that abietic acid may be used in the treatment of allergic reactions.

• Authors: N Nuray Ulusu, Dilek Ercil, M Koray Sakar, E Ferhan Tezcan
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 16 Issue 1 Pg. 88-90 (Feb 2002) ISSN: 0951-418X [Print] England
• PMID: 11807975 (Publication Type: Journal Article)
• Copyright: Copyright 2002 John Wiley & Sons, Ltd.

Chemical References

• Abietanes
• Diterpenes
• Enzyme Inhibitors
• Phenanthrenes
• Plant Extracts
• Linoleic Acid
• Lipoxygenase
• abietic acid

Topics

• Abies
• Abietanes
• Diterpenes (chemistry, isolation & purification, pharmacology)
• Dose-Response Relationship, Drug
• Enzyme Inhibitors (chemistry, pharmacology)
• Linoleic Acid (pharmacology)
• Lipoxygenase (metabolism)
• Molecular Structure
• Phenanthrenes (chemistry, isolation & purification, pharmacology)
• Plant Extracts (chemistry, isolation & purification, pharmacology)