Relationship between prostatic atrophy and apoptosis in the canine spontaneous benign prostatic hyperplasia (BPH) following chlormadinone acetate (CMA).

Abstract

The effect of a synthetic steroidal antiandrogen, chlormadinone acetate (CMA), on spontaneous benign prostatic hyperplasia (BPH) in dogs was investigated. Male beagle dogs (5-8 years old) were divided into four experimental groups. Group 1 consisted of untreated controls. Groups 2 to 4 received CMA 0.03, 0.1, and 0.3 mg/kg/day, p.o., respectively, for 6 months. In group 1, glandular hyperplasia of the prostate was clearly detected. In groups 2 to 4, CMA produced marked atrophy of the glandular epithelium. The interacinar fibro-muscular stroma was prominent. To evaluate the frequency of apoptosis, we counted the positive cells stained by the nick end labeling method. In group 1, the apoptotic index was 0.76 +/- 0.03%. In groups 2 to 4, apoptotic index were 15.41 +/- 1.26%, 2.63 +/- 0.98% and 1.45 +/- 0.85%, respectively. Apoptotic cell death was mainly observed in the glandular may be epithelial cells. Based on our data, regression of BPH after treatment with CMA apoptotic cell death.

• Authors: M Murakoshi, R Ikeda, N Fukui, T Nakayama
• Journal: The Tokai journal of experimental and clinical medicine (Tokai J Exp Clin Med) Vol. 26 Issue 2 Pg. 71-5 (Jul 2001) ISSN: 0385-0005 [Print] Japan
• PMID: 11806444 (Publication Type: Journal Article)

Chemical References

• Androgen Antagonists
• Progesterone Congeners
• Chlormadinone Acetate

Topics

• Androgen Antagonists (pharmacology, therapeutic use)
• Animals
• Apoptosis (drug effects)
• Atrophy
• Chlormadinone Acetate (pharmacology, therapeutic use)
• Dogs
• Male
• Progesterone Congeners (pharmacology, therapeutic use)
• Prostate (pathology)
• Prostatic Hyperplasia (drug therapy, pathology)