Abstract | OBJECTIVES/HYPOTHESIS: STUDY DESIGN: Retrospective clinical investigation. METHODS: A total of 55 to 65 units of Botox were injected under sonographic control into the left and right parotid and submandibular glands of four patients with hypersalivation resulting from head and neck carcinoma, tracheostomy, and "idiopathic" hypersalivation disorder. At defined time intervals following injection, flow rate, total protein and immunoglobulin A content, and the enzymatic activities of amylase, acid phosphatase, and kallikrein were determined in the saliva. The patients were clinically examined to assess the severity of their symptoms, including sonographic control of the major salivary glands. RESULTS: All four patients reported distinct improvement of their symptoms within 1 week after injection. Salivary flow rate had considerably dropped, whereas the concentrations of the salivary components were much increased. Sonography did not reveal any changes of the salivary gland parenchyma. Therapeutic side effects were absent. CONCLUSIONS:
|
Authors | Maik Ellies, Rainer Laskawi, Saskia Rohrbach-Volland, Christian Arglebe, Wolfgang Beuche |
Journal | The Laryngoscope
(Laryngoscope)
Vol. 112
Issue 1
Pg. 82-6
(Jan 2002)
ISSN: 0023-852X [Print] United States |
PMID | 11802043
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Aged
- Botulinum Toxins, Type A
(administration & dosage)
- Humans
- Injections
- Male
- Middle Aged
- Parotid Gland
(diagnostic imaging, drug effects)
- Salivation
(drug effects)
- Secretory Rate
(drug effects)
- Sialorrhea
(diagnostic imaging, drug therapy, etiology)
- Submandibular Gland
(diagnostic imaging, drug effects)
- Treatment Outcome
- Ultrasonography
|