Abstract | RATIONALE AND OBJECTIVES: Magnetic Resonance Imaging (MRI) has proved to provide noninvasive methods to investigate the functional repercussion of myocardial infarction and to measure infarct size with specific contrast agents. In this study, we evaluate whether the combination of T2-weighted and contrast-enhanced T1-weighted MRI could detect and discern necrotic and ischemic, but salvageable, myocardium. METHODS: RESULTS: There was a strong correlation between of postcontrast T1-weighted MRI and histomorphometry (r2 = 0.98, P < 0.01). T2-weighted MRI overestimated the infarct size by 10.5% +/- 4.3% of left ventricular area. A good correlation was found between hyperintense areas on T2-weighted images and the percentage of dysfunctional areas on cine MRI (r2 = 0.84, P < 0.01). In regions with increased signal intensity on T2-weighted MRI, a decreased maximal systolic thickening (11.8% +/- 4.9%, P = 0.043) was found. CONCLUSION: In this study, the difference between the hyperintense areas on T2-weighted and enhanced T1-weighted images after myocardial infarction likely represents viable myocardium.
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Authors | Steven Dymarkowski, Yicheng Ni, Yi Miao, Jan Bogaert, Frank Rademakers, Hilde Bosmans, Guy Marchal |
Journal | Investigative radiology
(Invest Radiol)
Vol. 37
Issue 2
Pg. 77-85
(Feb 2002)
ISSN: 0020-9996 [Print] United States |
PMID | 11799331
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Contrast Media
- Mesoporphyrins
- Metalloporphyrins
- gadophrin-2
- Gadolinium
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Topics |
- Animals
- Contrast Media
- Dogs
- Female
- Gadolinium
- Magnetic Resonance Imaging
- Magnetic Resonance Imaging, Cine
- Male
- Mesoporphyrins
- Metalloporphyrins
- Myocardial Infarction
(pathology)
- Myocardial Reperfusion Injury
(pathology)
- Myocardium
(pathology)
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