| Abstract | BACKGROUND: Metastatic breast cancer is a common clinical entity, and its treatment is still a major clinical problem in modern oncology. Both cisplatin (CDDP) and 5-fluorouracil (5-FU) are effective agents. PATIENTS AND METHODS: In this retrospective study, the therapeutic efficacy and tolerability of CDDP and continuous infusion of 5-FU were evaluated in patients with pretreated metastatic breast cancer. 16 patients were surveyed. All of them were pretreated with anthracyclines in an adjuvant and/or therapeutic setting. Eight of them also received taxanes after the failure of anthracyclines. CDDP at 80 mg/m(2) for 1 day and 5-FU at 1,000 mg/m(2) as a continuous 24-hour infusion for 5 consecutive days were administrated every 3 weeks. RESULTS: 13 patients were included in response analysis. Because of severe toxicity, chemotherapy protocols of 3 patients were stopped after the first cycle. The objective response rate (partial response) was 46%. No complete response was observed. The median response duration was 5 (3.5-7) months in the response group. Favorable objective responses were observed more frequently in cases with skin metastasis. Five out of 6 patients who attained partial remission had skin metastasis. Response rates were similar in patients pretreated with taxanes and in those not pretreated with taxanes (75 vs. 80%). The most serious toxicity was myelosuppression (25%). CONCLUSIONS: Although this study is based on only a limited number of patients, the combination of CDDP and 5-FU can be recommended in patients refractory to both anthracyclines and taxanes and especially in cases of skin metastasis with a good performance status. |
| Authors | U Coşkun, N Gunel, D Yamac, A E Altinova
(Affiliation: Department of Medical Oncology, Gazi University Medical School, Ankara, Turkey. ugurcos at hotmail.com)
|
| Journal | Onkologie
(Onkologie)
Vol. 24
Issue 6
Pg. 576-9
(Dec 2001)
ISSN: 0378-584X Switzerland |
| PMID | 11799313
(Publication Type: Journal Article)
|
| Copyright | Copyright 2001 S. Karger GmbH, Freiburg |
| Chemical References |
- Bridged Compounds
- Taxoids
- Cisplatin
- taxane
- Fluorouracil
|
| Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, adverse effects)
- Breast Neoplasms
(drug therapy)
- Bridged Compounds
(administration & dosage)
- Cisplatin
(administration & dosage, adverse effects)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Female
- Fluorouracil
(administration & dosage, adverse effects)
- Humans
- Infusions, Intravenous
- Middle Aged
- Premedication
- Skin Neoplasms
(drug therapy, secondary)
- Taxoids
- Treatment Outcome
|
