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[Aldolase].

Abstract
Aldolase (EC 4.1.2.13) plays an important role in glucose metabolism. Aldolase has a molecular weight of 160 kDa and has three isozymes, namely aldolase A, B and C. The enzyme is probably present in all cells; it occurs in particularly large quantities in the muscles, liver and brain. An increase in serum aldolase is found in myotonic muscular disease, such as progressive muscular dystrophy and polymyositis. The enzyme rises in myocardial infarction, reaches a maximum within 24-48 hours and returns to normal in the course of five days. In these muscular diseases, aldolase A isozyme is elevated. Aldolase activity, especially B isozyme, in serum rises to very high levels in acute hepatitis, but is slightly elevated in cirrhosis, chronic hepatitis and obstructive jaundice. Aldolase becomes elevated in serum with malignant tumors, and isozyme A is predominant in serum. Erythrocytes are also rich in aldolase, and the enzyme rises in hemolytic anemia.
AuthorsK Taguchi, Y Takagi
JournalRinsho byori. The Japanese journal of clinical pathology (Rinsho Byori) Vol. Suppl 116 Pg. 117-24 (Nov 2001) ISSN: 0047-1860 [Print] Japan
PMID11797371 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Biomarkers
  • Isoenzymes
  • Fructose-Bisphosphate Aldolase
Topics
  • Acute Disease
  • Anemia, Hemolytic (diagnosis)
  • Animals
  • Biomarkers (blood)
  • Clinical Enzyme Tests (methods)
  • Fructose-Bisphosphate Aldolase (blood)
  • Hepatitis (diagnosis)
  • Humans
  • Isoenzymes (blood)
  • Muscular Dystrophies (diagnosis)
  • Myocardial Infarction (diagnosis)
  • Neoplasms (diagnosis)
  • Reference Values

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