Abstract | OBJECTIVE: METHODS: RESULTS: MMP-3 serum levels were significantly increased in patients with active RA, psoriatic arthritis, and polymyalgia rheumatica, whether treated or not by corticosteroids, and in female patients with acute crystal arthritis. MMP-3 serum levels were normal in steroid-free patients with active cutaneo-articular or renal SLE, systemic sclerosis, and vasculitides but were significantly increased in steroid treated patients. MMP-3 levels were normal in fibromyalgia, osteoarthritis, ankylosing spondylitis, and acute inflammatory controls. MMP-3 was significantly correlated with CRP in RA (r=0.5, p=0.0004) but not in any of the other disease groups. CONCLUSIONS:
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Authors | C Ribbens, M Martin y Porras, N Franchimont, M-J Kaiser, J-M Jaspar, P Damas, F A Houssiau, M G Malaise |
Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 61
Issue 2
Pg. 161-6
(Feb 2002)
ISSN: 0003-4967 [Print] England |
PMID | 11796404
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Glucocorticoids
- C-Reactive Protein
- Prednisolone
- Matrix Metalloproteinase 3
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Arthritis, Psoriatic
(blood)
- Arthritis, Rheumatoid
(blood, drug therapy)
- Biomarkers
(blood)
- C-Reactive Protein
(analysis)
- Case-Control Studies
- Female
- Fibromyalgia
(blood)
- Glucocorticoids
(therapeutic use)
- Humans
- Lupus Erythematosus, Systemic
(blood)
- Male
- Matrix Metalloproteinase 3
(blood)
- Middle Aged
- Osteoarthritis
(blood)
- Polymyalgia Rheumatica
(blood)
- Prednisolone
(therapeutic use)
- Scleroderma, Systemic
(blood)
- Spondylitis, Ankylosing
(blood)
- Statistics, Nonparametric
- Vasculitis
(blood)
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