Cytotoxic triterpenoides from Alismatis Rhizoma.

Abstract

Four prostane-type triterpenes were isolated from a methanol extract of Alismatis Rhizoma by bioassay-guided isolation using in vitro cytotoxic assay. The compounds were identified as alisol B 23-acetate (1), alisol C 23-acetate (2), alisol B (3), alisol A 24-acetate (4) by spectroscopic methods. Amongst the compounds, alisol B (3) showed significant cytotoxicity against SK-OV3, B16-F10, and HT1080 cancer cell lines with ED50 values of 7.5, 7.5, 4.9 microg/ml, respectively.

• Authors: S Lee, Y Kho, B Min, J Kim, M Na, S Kang, H Maeng, K Bae
• Journal: Archives of pharmacal research (Arch Pharm Res) Vol. 24 Issue 6 Pg. 524-6 (Dec 2001) ISSN: 0253-6269 [Print] Korea (South)
• PMID: 11794528 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Cholestenones
• alisol A 24-acetate
• alisol B monoacetate
• alisol C 23-acetate
• alisol B

Topics

• Animals
• Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
• Cholestenones (isolation & purification, pharmacology)
• Humans
• Mice
• Plants, Medicinal (chemistry)
• Tumor Cells, Cultured