Abstract | PURPOSE: MATERIALS AND METHODS: Between February 1986 and April 2000, 17 cadaveric renal transplants were performed in 11 females and 5 males with spina bifida. Mean age at transplantation was 20.2 years (range 10 to 35). Of the patients 11 were wheelchair bound and 5 were independently mobile. Before transplantation surgical management of the urological tract included clean intermittent self-catheterization in 3 cases, enterocystoplasty and clean intermittent self-catheterization in 8, and ileal conduit urinary diversion in 5. A total of 14 patients were on renal replacement therapy before receiving the graft. Cyclosporine based triple therapy was administered to maintain immunosuppression in all cases and antithymocytic globulin was given for induction in 7. RESULTS: Six grafts have failed, including 1 in a patient who underwent successful re- transplantation. Median graft survival was 7.23 years. Two patients died after graft nephrectomy. At a mean followup of 52.8 months (range 1 month to 14 years) 11 of 17 grafts are functioning with a mean serum creatinine of 112.7 +/- 29.4 mmol./l. CONCLUSIONS:
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Authors | Richard E Power, Kiaran J O'Malley, Dilly M Little, Mary G Donovan, Tom A Creagh, Denis M Murphy, David P Hickey |
Journal | The Journal of urology
(J Urol)
Vol. 167
Issue 2 Pt 1
Pg. 477-9
(Feb 2002)
ISSN: 0022-5347 [Print] United States |
PMID | 11792900
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Cadaver
- Child
- Female
- Follow-Up Studies
- Graft Survival
- Humans
- Kidney Failure, Chronic
(etiology, surgery)
- Kidney Transplantation
- Male
- Spinal Dysraphism
(complications)
- Treatment Outcome
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