Abstract |
The effects of SMP-300, an orally active, potent, and selective Na+/H+ exchange inhibitor, were evaluated and compared with those of nifedipine, propranolol, and nicorandil on three experimental angina models and on myocardial infarction in rats. SMP-300 (0.1-1 mg/kg, p.o.) reduced isoproterenol-induced ST segment depression in a dose-dependent manner. Its maximal effect was comparable to that reported for propranolol and greater than that of nifedipine. SMP-300 (0.3-1 mg/kg) reduced vasopressin-induced ST segment depression in a dose-dependent manner, and its maximal effect was comparable to those of nifedipine and nicorandil. SMP-300 (0.3-1 mg/kg, p.o.) and propranolol (100 mg/kg, p.o.) inhibited coronary artery occlusion-induced T-wave elevation, but nifedipine (3 mg/kg, p.o.) did not. SMP-300 (1 mg/kg, p.o.) reduced myocardial infarct size after 40 min of coronary artery occlusion followed by 24 h of reperfusion, but nifedipine (3 mg/kg, p.o.) or propranolol (100 mg/kg, p.o.) did not. This study provides support for the future use of a Na+/H+ exchange inhibitor as an anti-anginal drug with a novel mode of action.
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Authors | Setsuko Yamamoto, Kazuki Matsui, Masao Sasabe, Naohito Ohashi |
Journal | Journal of cardiovascular pharmacology
(J Cardiovasc Pharmacol)
Vol. 39
Issue 2
Pg. 234-41
(Feb 2002)
ISSN: 0160-2446 [Print] United States |
PMID | 11791009
(Publication Type: Journal Article)
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Chemical References |
- Azocines
- Pyrroles
- SMP-300
- Sodium-Hydrogen Exchangers
- Vasodilator Agents
- Vasopressins
- Nicorandil
- Propranolol
- Nifedipine
- Isoproterenol
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Topics |
- Administration, Oral
- Angina Pectoris
(chemically induced, drug therapy)
- Animals
- Azocines
(pharmacology, therapeutic use)
- Coronary Disease
(complications)
- Electrocardiography
- Isoproterenol
- Male
- Myocardial Infarction
(drug therapy, etiology, pathology)
- Myocardial Reperfusion Injury
(complications)
- Myocardium
(metabolism, pathology)
- Nicorandil
(pharmacology)
- Nifedipine
(pharmacology)
- Propranolol
(pharmacology)
- Pyrroles
(pharmacology, therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Rats, Wistar
- Sodium-Hydrogen Exchangers
(antagonists & inhibitors, metabolism)
- Vasodilator Agents
(pharmacology)
- Vasopressins
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