HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease.

Abstract
The authors used 2-(1-(6-[(2-[18F]fluoroethyl)(methyl)amino]-2-naphthyl)ethylidene)malononitrile ([18F]FDDNP), a hydrophobic radiofluorinated derivative of 2-(1-[6-(dimethylamino)-2-naphthyl]ethylidene)malononitrile (DDNP), in conjunction with positron emission tomography to determine the localization and load of neurofibrillary tangles (NFTs) and beta-amyloid senile plaques (APs) in the brains of living Alzheimer disease (AD) patients. Previous work illustrated the in vitro binding characteristics of [18F]FDDNP to synthetic beta-amyloid(1-40) fibrils and to NFTs and APs in human AD brain specimens. In the present study, greater accumulation and slower clearance was observed in AP- and NFT-dense brain areas and correlated with lower memory performance scores. The relative residence time of the probe in brain regions affected by AD was significantly greater in patients with AD (n=9) than in control subjects (n=7; p=0.0007). This noninvasive technique for monitoring AP and NFT development is expected to facilitate diagnostic assessment of patients with AD and assist in response-monitoring during experimental treatments.
AuthorsKooresh Shoghi-Jadid, Gary W Small, Eric D Agdeppa, Vladimir Kepe, Linda M Ercoli, Prabha Siddarth, Stephen Read, Nagichettiar Satyamurthy, Andrej Petric, Sung-Cheng Huang, Jorge R Barrio
JournalThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry (Am J Geriatr Psychiatry) 2002 Jan-Feb Vol. 10 Issue 1 Pg. 24-35 ISSN: 1064-7481 [Print] England
PMID11790632 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • 1-(6-((2-fluoroethyl)(methyl)amino)naphthalen-2-yl)ethanone
  • 2-(1-(6-((2-fluoroethyl)(methyl)amino)-2-naphthyl)ethylidene)malononitrile
  • Amyloid beta-Peptides
  • Fluorescent Dyes
  • Naphthalenes
  • Nitriles
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
Topics
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease (diagnostic imaging, pathology)
  • Amyloid beta-Peptides (metabolism)
  • Brain (diagnostic imaging, metabolism, pathology)
  • Case-Control Studies
  • Female
  • Fluorescent Dyes
  • Fluorodeoxyglucose F18
  • Humans
  • Male
  • Memory
  • Middle Aged
  • Naphthalenes
  • Neurofibrillary Tangles (diagnostic imaging)
  • Neuropsychological Tests
  • Nitriles
  • Plaque, Amyloid (diagnostic imaging)
  • Predictive Value of Tests
  • Radiopharmaceuticals
  • Tomography, Emission-Computed (methods)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: