[The study on human leucocyte antigen DQ region genes polymorphism in unexplained habitual abortion patients].

Abstract

OBJECTIVE:

To investigate whether human leucocyte antigen DQ (HLA-DQ) genes polymorphism are related to the susceptibility to unexplained habitual abortion.

METHODS:

HLA-DQA1 and HLA-DQB1 gene typings are performed by polymerase chain reaction-restrictive fragment length polymorphism(PCR-RFLP) technique in 32 cases of unexplained habitual abortion and 54 women with normal pregnancy history.

RESULTS:

In unexplained habitual abortion group, the frequency of DQB1 * 0604, 0605 allele is increased significantly compared with that of controls(12.5% and 2.8%, P < 0.05) and the frequency of DQB1 * 0501, 0502 allele is decreased significantly (3.1% and 11.1%, P < 0.05). The frequency of DQA1 alleles do not differ significantly between two groups. Furthermore, the frequency of DQA1 * 01/DQB1 * 0604,0605 haplotype in patients is significantly increased than that of controls (12.5% and 2.8%, P < 0.05).

CONCLUSION:

The results suggest that DQB1 * 0604,0605 allele and DQA1 * 01/DQB1 * 0604,0605 haplotype may be a susceptible gene and haplotype of unexplained habitual abortion, while DQB1 * 0501,0502 allele may be a protective factor for habitual abortion.

• Authors: Q Lin, P Lu, X Wang
• Journal: Zhonghua fu chan ke za zhi (Zhonghua Fu Chan Ke Za Zhi) Vol. 36 Issue 5 Pg. 293-5 (May 2001) ISSN: 0529-567X [Print] China
• PMID: 11783381 (Publication Type: English Abstract, Journal Article)

Chemical References

• HLA-DQ Antigens

Topics

• Abortion, Habitual (genetics, immunology)
• Adult
• Female
• HLA-DQ Antigens (genetics)
• Humans
• Leukocytes (immunology)
• Middle Aged
• Polymorphism, Genetic
• Pregnancy