Abstract | OBJECTIVE: METHODS: RESULTS: Among 63 breast carcinoma patients, 19(30.2%) were RT-PCR positive for hMAM mRNA which was elevated with the tumor stage. None of the other cancer patients or those suffering from benign breast diseases were positive but only 1 of the 31 healthy volunteers gave detectable hMAM mRNA findings. hMAM mRNA was not detectable in the peripheral blood after operation in 6(32%) of 19 patients whose pre-operative test had been positive even though the hMAM mRNA expression increased with tumor stage. These results did not correlate with patients' stage, estrogen or pregnant receptor status. CONCLUSION: hMAM transcripts are detectable in the peripheral blood of some breast cancer patients. hMAM may be a novel candidate and a clinically useful breast tumor marker, especially in detecting micrometastasis.
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Authors | N Liu, W Zhang, Y Shao |
Journal | Zhonghua zhong liu za zhi [Chinese journal of oncology]
(Zhonghua Zhong Liu Za Zhi)
Vol. 23
Issue 4
Pg. 317-9
(Jul 2001)
ISSN: 0253-3766 [Print] China |
PMID | 11783116
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Mammaglobin A
- Neoplasm Proteins
- RNA, Messenger
- SCGB2A2 protein, human
- Uteroglobin
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Topics |
- Breast Neoplasms
(blood, genetics, pathology)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Mammaglobin A
- Middle Aged
- Neoplasm Metastasis
- Neoplasm Proteins
(genetics)
- Neoplasm Staging
- RNA, Messenger
(blood, genetics)
- Reverse Transcriptase Polymerase Chain Reaction
- Uteroglobin
(genetics)
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