Abstract | OBJECTIVE: To explore the relationship between primary liver cancer (PLC) and MC in drinking pond-ditch water. METHODS: Epidemiological and ecological assays, Meta-analysis and risk assessment were used in this study. Cyanotoxin ( Microcystin, MC) in the water of different sources was detected by ELISA. The F344 and HBVx transgenic mice were used to confirm the promotion effect on PLC and the synthetically carcinogenic effect of HBV, aflatoxin and MC. RESULTS: Using Meta-analysis the results of six case-control studies showed that the pooled odds ratio (OR) was 2.46 (95% CI 1.69-2.59), population attributable rick (PAR) was 30.39% (95% CI, 23.30%-37.47%), heterogeneity test P > 0.05. Eutrophication led to cyanobacterial bloom in the pond-ditch water. Cyanotoxin released from dead cyanobacteria was hepatotactic tumor promoter. In HBVx transgenic rats, hepatocellular carcinoma was induced by the joint administration of aflatoxin B1 and cyanotoxin. Epidemiological study showed that the recombined index of HBsAg, aflatoxin- albumin adducts and drinking of pond-ditch water correlated with PLC mortalities in 13 townships. CONCLUSION:
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Authors | S Yu, N Zhao, X Zi |
Journal | Zhonghua zhong liu za zhi [Chinese journal of oncology]
(Zhonghua Zhong Liu Za Zhi)
Vol. 23
Issue 2
Pg. 96-9
(Mar 2001)
ISSN: 0253-3766 [Print] China |
PMID | 11783030
(Publication Type: Journal Article)
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Chemical References |
- Microcystins
- Peptides, Cyclic
- Trans-Activators
- Viral Regulatory and Accessory Proteins
- hepatitis B virus X protein
- microcystin
- Aflatoxin B1
- Glutathione Transferase
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Topics |
- Aflatoxin B1
(toxicity)
- Animals
- Animals, Genetically Modified
- Carcinoma, Hepatocellular
(chemically induced, pathology)
- Child
- China
- Fresh Water
(chemistry)
- Glutathione Transferase
(drug effects, metabolism)
- Hepatectomy
- Humans
- Liver
(drug effects, enzymology, pathology)
- Liver Neoplasms
(chemically induced, pathology)
- Liver Neoplasms, Experimental
(chemically induced, pathology)
- Male
- Microcystins
- Peptides, Cyclic
(adverse effects, analysis)
- Rats
- Rats, Inbred F344
- Trans-Activators
(genetics, physiology)
- Viral Regulatory and Accessory Proteins
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