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[Efficacy of somatostatin analogs in the treatment of neuroendocrine tumours and paraneoplastic syndromes].

AbstractBACKGROUND:
The authors report their experience with octreotide LAR in the adjuvant treatment of 10 patients suffering from neuroendocrine tumours and paraneoplastic syndromes.
METHODS:
All patients were studied preoperatively using traditional radiology and scintigraphy using octreoscan.
RESULTS:
Octreoscan was positive in all cases for somatostatin receptors. All patients with neuroendocrine tumours underwent surgery of the primary neoplasm; treatment with somatostatin was commenced at a later stage.
CONCLUSIONS:
The authors' experience with octreotide LAR proved to be an efficacious means of controlling symptoms and stabilising disease without collateral effects. They conclude by affirming that octreotide LAR represents a valid therapeutic choice in the symptomatic treatment of neuroendocrine tumours.
AuthorsP Sperlongano, M De Falco, D Pisaniello, D Parmeggiani, U Parmeggiani
JournalMinerva endocrinologica (Minerva Endocrinol) Vol. 26 Issue 4 Pg. 293-5 (Dec 2001) ISSN: 0391-1977 [Print] Italy
Vernacular TitleEfficacia degli analoghi della somatostatina nel trattamento dei tumori neuroendocrini e delle sindromi paraneoplastiche.
PMID11782719 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antineoplastic Agents, Hormonal
  • Somatostatin
  • Octreotide
Topics
  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents, Hormonal (therapeutic use)
  • Chemotherapy, Adjuvant
  • Combined Modality Therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuroendocrine Tumors (drug therapy, surgery, therapy)
  • Octreotide (therapeutic use)
  • Paraneoplastic Syndromes (drug therapy, surgery, therapy)
  • Somatostatin (analogs & derivatives, therapeutic use)

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