Abstract | BACKGROUND: METHOD: After unsolicited referrals from their psychiatrists and careful consideration by the Massachusetts General Hospital Cingulotomy Assessment Committee (MGH-CAC), 5 patients were treated with limbic leucotomy. Their primary DSM-IV psychiatric diagnoses were either obsessive-compulsive disorder or schizoaffective disorder. Comorbid severe, treatment-refractory self-mutilation was an additional target symptom. Outcome was measured by an independent observer using the Clinical Global Improvement. Current Global Psychiatric-Social Status Rating, and DSM-IV Global Assessment of Functioning scales in addition to telephone interviews with patients, families, their psychiatrists, and treatment teams. The mean postoperative follow-up period was 31.5 months. RESULTS: All measures indicated sustained improvement in 4 of 5 patients. In particular, there was a substantial decrease in self-mutilation behaviors. Postoperative complications were transient in nature. and postoperative compared with preoperative neuropsychological assessments revealed no clinically significant deficits. CONCLUSION:
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Authors | B H Price, I Baral, G R Cosgrove, S L Rauch, A A Nierenberg, M A Jenike, E H Cassem |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 62
Issue 12
Pg. 925-32
(Dec 2001)
ISSN: 0160-6689 [Print] United States |
PMID | 11780871
(Publication Type: Case Reports, Journal Article)
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Topics |
- Adult
- Brain Mapping
- Dominance, Cerebral
(physiology)
- Female
- Follow-Up Studies
- Gyrus Cinguli
(physiopathology, surgery)
- Humans
- Limbic System
(physiopathology, surgery)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Obsessive-Compulsive Disorder
(physiopathology, psychology, surgery)
- Postoperative Complications
(physiopathology, psychology)
- Psychiatric Status Rating Scales
- Psychosurgery
- Psychotic Disorders
(physiopathology, psychology, surgery)
- Self Mutilation
(physiopathology, psychology, surgery)
- Treatment Outcome
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