Abstract | OBJECTIVE: To provide evidence for using micronucleated cells of exfoliated oral mucosa cells in diagnosis and treatment of oral leukoplakias and chemopreventive studies of oral cancer. METHODS: RESULTS: Frequency of micronucleated cells of exfoliated oral mucosa cells in oral leukoplakia lesions was higher than that of normal persons. Frequency of micronucleated cells of exfoliated oral mucosa cells had a positive correlation with oral leukoplakia lesions(r = 0.9997, P < 0.001) and with frequency of micronucleated cells of oral mucosa cells (P < 0.001). CONCLUSIONS: Frequency of micronucleated cells of exfoliated oral mucosa cells are useful markers to the clinician to predict oral leukoplakia behaviour and prognosis and substitute for frequency of micronucleated cells of oral mucosa cells as intermediate endpoint in chemopreventive trials.
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Authors | Z Sun, N Li, Z Zhang |
Journal | Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
(Zhonghua Kou Qiang Yi Xue Za Zhi)
Vol. 35
Issue 6
Pg. 439-41
(Nov 2000)
ISSN: 1002-0098 [Print] China |
PMID | 11780528
(Publication Type: English Abstract, Journal Article)
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Topics |
- Adult
- Aged
- Exfoliation Syndrome
(pathology)
- Female
- Humans
- Leukoplakia, Oral
(diagnosis, pathology)
- Male
- Micronuclei, Chromosome-Defective
(pathology)
- Middle Aged
- Mouth Mucosa
(pathology)
- Mouth Neoplasms
(diagnosis, pathology)
- Statistics as Topic
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