Decreased dopamine D2 receptor binding in the anterior cingulate cortex in schizophrenia.

Abstract

BACKGROUND:

The clinical efficacy of dopamine D2 receptor antagonism on the psychotic symptoms of schizophrenia has been widely demonstrated. However, most in vivo imaging studies have not been able to detect significant changes in striatal D2 receptors in schizophrenia. On the other hand, a number of studies have reported abnormalities in the cerebral cortex of schizophrenia. The aim of this study was to examine the extrastriatal D2 receptors of patients with schizophrenia.

METHODS:

Eleven drug-naive male patients with schizophrenia were examined with positron emission tomography using carbon 11-labeled FLB 457. Symptoms were assessed using the Brief Psychiatric Rating Scale. Eighteen healthy controls were used for comparison. Region-of-interest analysis was performed using the reference tissue method, and binding potential (BP) was used for the index of dopamine D2 receptor binding.

RESULTS:

The BP value was significantly lower, by about 12.5%, in the anterior cingulate cortex in drug-naive patients with schizophrenia than in healthy controls. A significant negative correlation was observed between BP in the anterior cingulate cortex and the positive symptom score on Brief Psychiatric Rating Scale.

CONCLUSIONS:

The lower BP values indicate fewer D2 receptors in the anterior cingulate cortex in patients with schizophrenia. Alterations in D2 receptor function in the extrastriatal region may underlie the positive symptoms of schizophrenia.

• Authors: Tetsuya Suhara, Yoshiro Okubo, Fumihiko Yasuno, Yasuhiko Sudo, Makoto Inoue, Tetsuya Ichimiya, Yoshifumi Nakashima, Kazuhiko Nakayama, Shuji Tanada, Kazutoshi Suzuki, Christer Halldin, Lars Farde
• Journal: Archives of general psychiatry (Arch Gen Psychiatry) Vol. 59 Issue 1 Pg. 25-30 (Jan 2002) ISSN: 0003-990X [Print] United States
• PMID: 11779278 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Dopamine Antagonists
• Pyrrolidines
• Receptors, Dopamine D2
• Salicylamides
• FLB 457

Topics

• Adult
• Brain Mapping
• Dopamine Antagonists (pharmacokinetics)
• Gyrus Cinguli (diagnostic imaging, physiopathology)
• Humans
• Male
• Psychiatric Status Rating Scales
• Pyrrolidines (pharmacokinetics)
• Receptors, Dopamine D2 (physiology)
• Reference Values
• Salicylamides (pharmacokinetics)
• Schizophrenia (diagnostic imaging, physiopathology)
• Schizophrenic Psychology
• Tomography, Emission-Computed