Choriocarcinoma of the gallbladder: treated with cisplatin-based chemotherapy.

Abstract

A case of non-gestational choriocarcinoma, primary in the gallbladder, is described. Pathology showed a mixture of adenocarcinoma and choriocarcinoma. A Medline search for the last 10 years has shown no similar cases reported. The use of cisplatin-based chemotherapy to treat non-gestational choriocarcinoma has also not been described. This patient showed a rapidly progressive disease as described in other reported cases of non-gestational choriocarcinoma. However, cisplatin-based chemotherapy, in this patient, produced a partial response defined as significantly decreased beta-HCG titers (more than 50%), and with stable appearance or slightly improvement of hepatic metastasis and survival for 1 yr.

• Authors: J C Wang, S Angeles, P Chak, A B Platt, N Nimmagadda
• Journal: Medical oncology (Northwood, London, England) (Med Oncol) Vol. 18 Issue 2 Pg. 165-9 ( 2001) ISSN: 1357-0560 [Print] United States
• PMID: 11778764 (Publication Type: Case Reports, Journal Article)

Chemical References

• Chorionic Gonadotropin, beta Subunit, Human
• Etoposide
• Cisplatin

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Choriocarcinoma (drug therapy, pathology)
• Chorionic Gonadotropin, beta Subunit, Human (blood)
• Cisplatin (administration & dosage)
• Disease Progression
• Etoposide (administration & dosage)
• Fatal Outcome
• Female
• Gallbladder Neoplasms (drug therapy, pathology)
• Humans
• Immunohistochemistry
• Middle Aged