Abstract | OBJECTIVE: To investigate the significance of TNF-alpha and its soluble receptors (sTNFR-I and sTNFR-II) in differentiating benign and malignant pleural disease. METHODS: RESULTS:
TNF-alpha level in the serum of tuberculosis patients with pleural effusion is (16.4 +/- 6.2) ng/L, lower than that in the serum of malignant pleural effusion patients (20.5 +/- 10.9) ng/L (P < 0.01), but higher than that in the serum of normal control (11.0 +/- 2.9) ng/L (P < 0.01). TNF-alpha level in the pleural effusion of tuberculosis patients is (29.4 +/- 10.3) ng/L, significantly higher than that of malignant pleural effusion (11.7 +/- 2.0) ng/L (P < 0.01). The sTNFR-I and sTNFR-II level in the serum of malignant pleural effusion is (1,132 +/- 303) ng/L and (1,548 +/- 489) ng/L respectively, significantly higher than that in tuberculosis pleural effusion which is (979 +/- 146) ng/L and (977 +/- 93) ng/L (P < 0.01) respectively. The sTNFR-I and sTNFR-II level in malignant pleural effusion is (1,404 +/- 306) ng/L and (2,195 +/- 418) ng/L respectively, markedly higher than those in tuberculosis pleural effusion which is (1,185 +/- 215) ng/L and (1,195 +/- 300) ng/L (P < 0.01). CONCLUSION:
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Authors | J Zhou, Q Zhao, H Yao |
Journal | Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
(Zhonghua Jie He He Hu Xi Za Zhi)
Vol. 23
Issue 3
Pg. 158-60
(Mar 2000)
ISSN: 1001-0939 [Print] China |
PMID | 11778489
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antigens, CD
- Receptors, Tumor Necrosis Factor
- Receptors, Tumor Necrosis Factor, Type I
- Receptors, Tumor Necrosis Factor, Type II
- Tumor Necrosis Factor-alpha
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Topics |
- Adult
- Aged
- Antigens, CD
(analysis)
- Diagnosis, Differential
- Female
- Humans
- Male
- Middle Aged
- Pleural Effusion
(chemistry)
- Pleural Effusion, Malignant
(diagnosis)
- Receptors, Tumor Necrosis Factor
(analysis)
- Receptors, Tumor Necrosis Factor, Type I
- Receptors, Tumor Necrosis Factor, Type II
- Tuberculosis, Pleural
(diagnosis)
- Tumor Necrosis Factor-alpha
(analysis)
|