Paired tumor marker of soluble E-selectin and its ligand sialyl Lewis A in colorectal cancer.

Abstract

BACKGROUND:

Better diagnosis of metastatic disease has been pursued by oncologists: however, many of the tumor markers have been still controversial. Our purpose was to estimate the usefulness of soluble E-selectin and its ligand sialyl Lewis A for more accurate diagnosis as a combined tumor marker for metastases in colorectal cancer.

METHODS:

E-selectin and sialyl Lewis A, collected from preoperative blood, were measured of its levels in 54 patients with colorectal cancer classified according to Dukes' stage. E-selectin was assayed by enzyme-linked immunosorbent assay, whereas sialyl Lewis A was quantified by enzyme immunoassay using immunoclone kit.

RESULTS:

The elevation in the level of E-selectin was significantly higher in Dukes' D group than that of healthy volunteers (P < 0.001, Fisher's procedure of least significance test), Dukes' A (P = 0.01), B (P = 0.025) and C (P < 0.01). Significantly higher level of sialyl Lewis A was shown in the group of metastases than that of non-metastases (P < 0.0068. Student's t-test). Paired elevation of E-selectin and sialyl Lewis A was significantly higher in the hematogenous metastases than non-metastases (P < 0.001, Fisher exact test).

CONCLUSIONS:

These results suggest that E-selectin could play some role in the progress of hematogenous metastases. The elevation of E-selectin alone or both E-selectin and sialyl Lewis A may be one of the useful indexes for more precise diagnosis of hematogenous metastases of human colorectal cancer.

• Authors: K Ito, C L Ye, K Hibi, C Mitsuoka, R Kannagi, K Hidemura, H Ando, Y Kasai, S Akiyama, A Nakao
• Journal: Journal of gastroenterology (J Gastroenterol) Vol. 36 Issue 12 Pg. 823-9 (Dec 2001) ISSN: 0944-1174 [Print] Japan
• PMID: 11777210 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• CA-19-9 Antigen
• E-Selectin
• Ligands
• Oligosaccharides

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (blood)
• CA-19-9 Antigen
• Carcinoma (blood, diagnosis, secondary)
• Colorectal Neoplasms (blood, diagnosis, pathology)
• E-Selectin (blood)
• Female
• Humans
• Ligands
• Liver Neoplasms (blood, diagnosis, secondary)
• Lymphatic Metastasis (diagnosis)
• Male
• Middle Aged
• Neoplasm Staging
• Oligosaccharides (blood)
• Peritoneal Neoplasms (blood, diagnosis, secondary)