Abstract | OBJECTIVE: METHODS: RESULTS: Few apoptotic cells were found in NPC, the AR significantly lower than that of chronic nasopharyngitis (P < 0.01). The frequency of expression of p16 and bcl-2 in NPC was 28.8% (21/73) and 81.2% (59/73), respectively, while that in chronic nasopharyngitis was 90% (18/20) and 15% (3/20), respectively. In NPC, expression of p16 was positively correlated, while bcl-2 negatively correlated with the AR (P < 0.01). According to 3-year follow up, the survival rate was higher in NPC patients with AR > 2.0 and negative bcl-2 expression, whereas that was higher in patients with positive expression of p16. CONCLUSION: Apoptosis is inhibited in NPC which may be related to p16 and bcl-2 gene dysregulation. Apoptosis correlates with prognosis in NPC patients.
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Authors | J Li, A Tang, G Huang |
Journal | Zhonghua zhong liu za zhi [Chinese journal of oncology]
(Zhonghua Zhong Liu Za Zhi)
Vol. 22
Issue 2
Pg. 158-60
(Mar 2000)
ISSN: 0253-3766 [Print] China |
PMID | 11776648
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Cyclin-Dependent Kinase Inhibitor p16
- Genetic Markers
- Proto-Oncogene Proteins c-bcl-2
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Topics |
- Adolescent
- Adult
- Aged
- Apoptosis
(genetics)
- Cyclin-Dependent Kinase Inhibitor p16
(biosynthesis, genetics)
- Female
- Gene Expression
- Genetic Markers
(genetics)
- Humans
- Male
- Middle Aged
- Nasopharyngeal Neoplasms
(genetics, metabolism, mortality, pathology)
- Proto-Oncogene Proteins c-bcl-2
(biosynthesis, genetics)
- Survival Analysis
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