Abstract |
The aim of this randomized, placebo-controlled study was to evaluate the effect of local treatment with Essaven gel (EG) in comparison with placebo in 30 patients with superficial vein thrombosis (SVT). The 4-week study evaluated the average skin temperature and an analogue symptomatic score. Below-knee SVT was associated with large varicose veins. In patients treated with active EG the decrease in score and in the average, composite skin temperature was significantly larger than in the placebo and control groups. No intolerance was observed. The decrease in score and temperature in the placebo group was mainly due to skin manipulation and massage. In conclusion, treatment with EG in SVT improves symptoms and decreases skin temperature faster. This study confirms earlier observations on the effective use of EG in SVT.
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Authors | M T De Sanctis, M R Cesarone, L Incandela, G Belcaro, M Griffin |
Journal | Angiology
(Angiology)
Vol. 52 Suppl 3
Pg. S57-62
(Dec 2001)
ISSN: 0003-3197 [Print] United States |
PMID | 11775651
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Drug Combinations
- Fibrinolytic Agents
- Phospholipids
- Escin
- Essaven Gel
- Heparin
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Topics |
- Administration, Topical
- Drug Combinations
- Escin
(administration & dosage)
- Female
- Fibrinolytic Agents
(administration & dosage)
- Heparin
(administration & dosage)
- Humans
- Male
- Middle Aged
- Phospholipids
(administration & dosage)
- Skin Temperature
(drug effects)
- Venous Thrombosis
(drug therapy)
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