[The experiment of pegylated liposomal doxorubicin to therapy tongue cancer and metastases lymph nodes].

Abstract

OBJECTIVE:

To investigate the effects of pegylated liposmal doxorubicin (PLD) in treating animal model of tongue cancer.

METHODS:

The tongue cancer model was established in 70 goldn hamsters, and PLD was injected. The free doxorubicin and its concentration in circulating blood and lymph nodes, the weight of animals, volume of tumor, were defected.

RESULTS:

Tumor inhibition effect of the PLD group was higher than controls.

CONCLUSIONS:

PLD can be regarded as a valuable drug system to treat oral cancer.

• Authors: S Chen, J Pan, X Liao
• Journal: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology (Zhonghua Kou Qiang Yi Xue Za Zhi) Vol. 36 Issue 5 Pg. 338-40 (Sep 2001) ISSN: 1002-0098 [Print] China
• PMID: 11769644 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Drug Carriers
• Liposomes
• Doxorubicin

Topics

• Animals
• Antineoplastic Agents (blood, therapeutic use)
• Cricetinae
• Disease Models, Animal
• Doxorubicin (blood, therapeutic use)
• Drug Carriers
• Drug Delivery Systems
• Liposomes (administration & dosage, chemistry)
• Lymphatic Metastasis
• Tongue Neoplasms (blood, drug therapy, pathology)
• Treatment Outcome