Mevalonate pyrophosphate decarboxylase in stroke-prone spontaneously hypertensive rat is reduced from the age of two weeks.

Abstract

We carried out a comparison of tissue distribution of mevalonate pyrophosphate decarboxylase (MPD) between normotensive Wistar Kyoto rat (WKY) and stroke-prone spontaneously hypertensive rat (SHRSP) using Western blotting. However, there was no difference in tissue distribution of MPD between WKY and SHRSP, expect in brain and liver. We then compared the MPD between WKY and SHRSP liver at several weeks of age. We found that MPD in the liver as well as brain of SHRSP was significantly reduced from two weeks of age. This data is useful to identify or understand the mechanism underlying the reduced amount of MPD in SHRSP.

• Authors: A Michihara, M Sawamura, Y Yamori, K Akasaki, H Tsuji
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 24 Issue 12 Pg. 1417-9 (Dec 2001) ISSN: 0918-6158 [Print] Japan
• PMID: 11767113 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Carboxy-Lyases
• pyrophosphomevalonate decarboxylase

Topics

• Aging (metabolism)
• Animals
• Animals, Newborn (metabolism)
• Carboxy-Lyases (metabolism)
• Hypertension (enzymology, physiopathology)
• Male
• Rats
• Rats, Inbred SHR (metabolism)
• Rats, Inbred WKY
• Stroke (enzymology, physiopathology)
• Tissue Distribution (physiology)