Abstract | OBJECTIVE AND DESIGN: MATERIALS AND METHODS:
PJ34 (at doses of 0.03-30 mg/kg) was tested in rats and mice subjected to standard models of inflammation, with relevant parameters of inflammation measured using standard methods. RESULTS: CONCLUSIONS:
PJ34 provides significant, dose-dependent, anti-inflammatory effects in a variety of local inflammation models. Some of its actions are maintained in the post-treatment regimen and/or after discontinuation of treatment. We conclude that PARP inhibition offers a powerful means for reducing the severity of various forms of local inflammatory responses.
|
Authors | J G Mabley, P Jagtap, M Perretti, S J Getting, A L Salzman, L Virág, E Szabó, F G Soriano, L Liaudet, G E Abdelkarim, G Haskó, A Marton, G J Southan, C Szabó |
Journal | Inflammation research : official journal of the European Histamine Research Society ... [et al.]
(Inflamm Res)
Vol. 50
Issue 11
Pg. 561-9
(Nov 2001)
ISSN: 1023-3830 [Print] Switzerland |
PMID | 11766996
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Anti-Inflammatory Agents
- Enzyme Inhibitors
- N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride
- Phenanthrenes
- Poly(ADP-ribose) Polymerase Inhibitors
- NAD
- Adenosine Triphosphate
- Collagen
|
Topics |
- Adenosine Triphosphate
(metabolism)
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Arthritis
(drug therapy)
- Colitis
(drug therapy)
- Collagen
(immunology)
- Diabetes Mellitus, Experimental
(drug therapy)
- Dose-Response Relationship, Drug
- Endotoxemia
(drug therapy)
- Enzyme Inhibitors
(pharmacology)
- Male
- Mice
- Mice, Inbred DBA
- NAD
(metabolism)
- Peritonitis
(drug therapy)
- Phenanthrenes
(pharmacology)
- Poly(ADP-ribose) Polymerase Inhibitors
- Uveitis
(drug therapy)
|