[Analysis of HLA-DR in Mexican patients with pemphigus].

Abstract

UNLABELLED:

Pemphigus are a group of bullous skin disorders histologically characterized by intraepidermal acantholytic and circulating antibodies blisters due to directed against the cellular surface of keratinocytes. In Mexican patients with pemphigus, HLA antigens have not been studied as they have been for other populations; for this reason, a comparative, prospective, transversal and observational study has been done with 25 patients, 18 with pemphigus vulgaris and the other seven with pemphigus foliaceus. DNA was extracted by the salting-out method and HLA-DR was determined by amplification with PCR and allele-specific oligonucleotides (ASO).

RESULTS:

HLA-DR14 (DR6) is more common in patients with pemphigus vulgaris than in the healthy population, which corroborates with previous reports. On the other hand, as reported we also found that HLA-DR1 in Mexican population represents a higher risk for pemphigus foliaceus.

• Authors: M E Vega-Memije, M M Sáez de Ocariz-Gutiérrez, R Cortés-Franco, L Domínguez-Soto, J Granados-Arriola
• Journal: Gaceta medica de Mexico (Gac Med Mex) 2001 Nov-Dec Vol. 137 Issue 6 Pg. 535-40 ISSN: 0016-3813 [Print] Mexico
• Vernacular Title: Análisis de HLA-DR en pacientes mexicanos con pénfigo.
• PMID: 11766460 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• HLA-DR Antigens

Topics

• Adult
• Cross-Sectional Studies
• Female
• HLA-DR Antigens (blood)
• Humans
• Male
• Mexico
• Middle Aged
• Pemphigus (blood)
• Prospective Studies