C-reactive protein in patients who had operative fracture treatment.

C-reactive protein as an indicator of infection, may help to detect surgical complications early and provide a better outcome for patients. To obtain a baseline for the use of C-reactive protein, the kinetics of C-reactive protein levels of 330 patients who had operative fracture treatment were studied before and after surgery. All patients who had an uneventful postoperative course had similar evolution in their C-reactive protein values: the peak level, which occurred on the second postoperative day, depended on the region of trauma (femoral fractures, 15.4 mg/dL versus ankle fractures, 3.5 mg/dL) and reflected the extent of surgical trauma. Of 47 patients with complicated courses, C-reactive protein proved helpful as a marker in risk stratification and as an early indicator for infection. Of nine patients with a deep wound infection, a high rise of C-reactive protein was recorded, and seven patients showed a rise in the C-reactive protein level before the onset of clinical symptoms. A cut-off level of 14 mg/dL on the fourth day after surgery was recorded for the patients with deep wound infection.
AuthorsM A Scherer, M Neumaier, S von Gumppenberg
JournalClinical orthopaedics and related research (Clin Orthop Relat Res) Issue 393 Pg. 287-93 (Dec 2001) ISSN: 0009-921X [Print] United States
PMID11764361 (Publication Type: Journal Article)
Chemical References
  • C-Reactive Protein
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • C-Reactive Protein (analysis)
  • Female
  • Fractures, Bone (blood, surgery)
  • Humans
  • Male
  • Middle Aged
  • Postoperative Complications (diagnosis)
  • Postoperative Period
  • Prospective Studies

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