Desensitizing efficacy of a new dentifrice containing 5.0% potassium nitrate and 0.454% stannous fluoride.

Abstract

PURPOSE:

To evaluate the relative effectiveness provided by a new dentifrice containing 5.0% potassium nitrate and 0.454% stannous fluoride in a silica base (Colgate Sensitive Maximum Strength) for reducing dentin hypersensitivity over an 8-wk period, as compared to that provided by a commercially-available antihypersensitivity dentifrice containing 5.0% potassium nitrate and 0.76% sodium monofluorophosphate in a dicalcium phosphate base (Fresh Mint Sensodyne dentifrice).

MATERIALS AND METHODS:

To qualify for participation in this examiner-blind study, male and female adults from the San Francisco, California area were required to present with tactile and air blast dentin hypersensitivity in at least 2 non-molar teeth at two examinations, spaced 1 wk apart. Qualifying subjects were randomized into two treatment groups, which were balanced for gender, age, and baseline sensitivity scores. Subjects were provided with a soft-bristled toothbrush. Examinations for tactile and air blast sensitivity were repeated after 4 wks' use of the study dentifrices, and again after 8 wks' usage.

RESULTS:

101 subjects complied with the protocol, and completed the entire study. After 4 wks, subjects assigned to the Colgate Sensitive Maximum Strength group exhibited a statistically significant improvement over the Fresh Mint Sensodyne dentifrice group with respect to tactile sensitivity scores, and a statistically significant improvement over the Sensodyne dentifrice group with respect to air blast sensitivity scores. Correspondingly significant improvements were presented after 8 wks. Thus, the results of this examiner-blind clinical study support the conclusion that Colgate Sensitive Maximum Strength dentifrice provided superior levels of control of tactile and air blast sensitivity than did the clinically tested, commercially-available Sensodyne anti-hypersensitivity dentifrice.

• Authors: T Schiff, Y Bonta, H M Proskin, W DeVizio, M Petrone, A R Volpe
• Journal: American journal of dentistry (Am J Dent) Vol. 13 Issue 3 Pg. 111-5 (Jun 2000) ISSN: 0894-8275 [Print] United States
• PMID: 11763944 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Cariostatic Agents
• Complex Mixtures
• Dentifrices
• Drug Combinations
• Nitrates
• Pharmaceutical Vehicles
• Phosphates
• Potassium Compounds
• Sensodyne
• Tin Fluorides
• colgate sensitive
• Silicon Dioxide
• Fluorides
• potassium nitrate

Topics

• Adult
• Aged
• Air
• Cariostatic Agents (administration & dosage, therapeutic use)
• Complex Mixtures
• Dentifrices (pharmacology, therapeutic use)
• Dentin Sensitivity (physiopathology, prevention & control)
• Drug Combinations
• Female
• Fluorides (therapeutic use)
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Nitrates (administration & dosage, therapeutic use)
• Pharmaceutical Vehicles
• Phosphates (therapeutic use)
• Potassium Compounds (administration & dosage, pharmacology, therapeutic use)
• Silicon Dioxide
• Single-Blind Method
• Statistics as Topic
• Tin Fluorides (administration & dosage, therapeutic use)
• Toothbrushing (instrumentation)
• Touch (physiology)
• Treatment Outcome