HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Effect of 5-aminoimidazole-4-carboxamide riboside (AICA-r) on isolated thoracic aorta responses in streptozotocin-diabetic rats.

Abstract
Diabetes mellitus alters the vascular responsiveness to several vasoconstrictors and vasodilators. 5-amino-4-imidazole-carboxamide riboside (AICA-r), a nucleoside corresponding to AICA-ribotide and an intermediate of the de novo pathway of purine biosynthesis, was recently proposed as a new insulinotropic tool in non-insulin-dependent diabetes mellitus. The aim of the present study was to define whether AICA-r affects altered vascular responsiveness to vasoconstrictors and vasodilators in the thoracic aorta of neonatal streptozotocin (STZ)-diabetic rats. The results of this study indicate that a 1-month treatment with AICA-r significantly increases the body weight in diabetic rats; significantly decreases the blood glucose level of diabetic rats (from 302+/-47 to 135+/-11 mg/dL, p<0.001); does not significantly affect the fast, slow, and total components of responses to noradrenaline in all the experimental groups; reverses the increased Emax values of noradrenaline in diabetic rats to near-control values; reverses the completely abolished responses of acetylcholine (pD2 and percent relaxation) in diabetic rats to control values; and reverses the decreased pD2 values of sodium nitroprussiate in diabetic rats to control values. In conclusion, AICA-r treatment in neonatal STZ-diabetic rats improved increased blood glucose levels, accelerated weight gain, reversed endothelial dysfunction, and normalized vascular responses.
AuthorsV Senses, S Ozyazgan, E Ince, M Tuncdemir, F Kaya, M Ozturk, G Sultuybek, A G Akkan
JournalJournal of basic and clinical physiology and pharmacology (J Basic Clin Physiol Pharmacol) Vol. 12 Issue 3 Pg. 227-48 ( 2001) ISSN: 0792-6855 [Print] England
PMID11762693 (Publication Type: Journal Article)
Chemical References
  • Blood Glucose
  • Ribonucleosides
  • Nitroprusside
  • Aminoimidazole Carboxamide
  • acadesine
  • Acetylcholine
  • Norepinephrine
Topics
  • Acetylcholine (pharmacology)
  • Aminoimidazole Carboxamide (analogs & derivatives, pharmacology)
  • Animals
  • Aorta, Thoracic (drug effects, physiology)
  • Blood Glucose (drug effects)
  • Body Weight (drug effects)
  • Diabetes Mellitus, Experimental (drug therapy, physiopathology)
  • Endothelium, Vascular (physiology)
  • Female
  • Injections, Intraperitoneal
  • Male
  • Nitroprusside (pharmacology)
  • Norepinephrine (pharmacology)
  • Rats
  • Rats, Wistar
  • Ribonucleosides (pharmacology)
  • Vasoconstriction (drug effects)
  • Vasodilation (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: