Abstract | BACKGROUND:
Endomyocardial fibrosis is a distinct form of heart disease leading to restrictive ventricular filling and cardiac failure. The disease is characterized by a marked thickening of the endocardium due to the deposition of dense fibrous tissue composed of wavy bundles of collagen. Changes in collagen composition and an abnormal increase in its concentration result in a stiffer myocardium and ventricular diastolic dysfunction. The nature of cardiac collagens and the relative proportions of collagen types in endomyocardial fibrosis have not been documented in the literature. METHODS AND RESULTS: CONCLUSIONS:
|
Authors | C Radhakumary, T V Kumari, C C Kartha |
Journal | Indian heart journal
(Indian Heart J)
2001 Jul-Aug
Vol. 53
Issue 4
Pg. 486-9
ISSN: 0019-4832 [Print] India |
PMID | 11759940
(Publication Type: Journal Article)
|
Chemical References |
- Collagen Type I
- Collagen Type III
|
Topics |
- Adult
- Collagen Type I
(metabolism)
- Collagen Type III
(metabolism, physiology)
- Electrophoresis, Polyacrylamide Gel
- Endomyocardial Fibrosis
(metabolism, physiopathology)
- Female
- Humans
- Male
- Middle Aged
- Myocardium
(metabolism)
|