Pibocin B, the first N-O-methylindole marine alkaloid, a metabolite from the Far-Eastern ascidian Eudistoma species.

Abstract

Pibocin B (2), the first representative of marine alkaloids with a unique structural feature, an N-O-methylindole group, was isolated from the Far-Eastern ascidian Eudistoma sp. Its structure has been established as (8 beta)-2-bromo-N-O-methyl-6,8-dimethylergoline on the basis of NMR data, FAB and MALDI-TOF MS, and chemical correlations. Pibocin B showed moderate cytotoxic activity against mouse Ehrlich carcinoma cells.

• Authors: T N Makarieva, A S Dmitrenok, P S Dmitrenok, B B Grebnev, V A Stonik
• Journal: Journal of natural products (J Nat Prod) Vol. 64 Issue 12 Pg. 1559-61 (Dec 2001) ISSN: 0163-3864 [Print] United States
• PMID: 11754612 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Anti-Infective Agents
• Antifungal Agents
• Antineoplastic Agents
• Indole Alkaloids
• pibocin A
• pibocin B

Topics

• Animals
• Anti-Bacterial Agents
• Anti-Infective Agents (chemistry, isolation & purification, pharmacology)
• Antifungal Agents (chemistry, isolation & purification, pharmacology)
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Bacillus subtilis (drug effects)
• Candida albicans (drug effects)
• Carcinoma, Ehrlich Tumor
• Crystallography, X-Ray
• Indole Alkaloids (chemistry, isolation & purification, pharmacology)
• Mice
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular
• Russia
• Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
• Staphylococcus aureus (drug effects)
• Tumor Cells, Cultured (drug effects)
• Urochordata (chemistry)