Abstract | BACKGROUND: Urinary C-terminal telopeptide of type I collagen (u-CTx) has been reported to be a sensitive biochemical marker of bone turnover. There have been two assays for urinary CTx, which are alpha-CTx and beta-CTx. A newly developed immunoassay for serum CTx (s-CTx) is now available for assessment of bone resorption. We evaluated the effects of aging, menopause, and osteoporosis on the measurements of serum CTx and compared them to urinary CTx assays. METHODS: In 79 premenopausal healthy women, 80 postmenopausal healthy women, 61 osteoporotic patients with vertebral fractures and 34 osteoporotic patients with hip fractures, s-CTx and urinary beta-CTx (u-betaCTx) were measured by ELISAs, and urinary alpha-CTx (u-alphaCTx) was measured by an RIA. RESULTS: In all subjects, s-CTx significantly correlated with both u-alphaCTx (r=0.54) and u-betaCTx (r=0.51). There was no significant difference among s-CTx, u-alphaCTx and u-betaCTx in the T-scores of the postmenopausal group over the premenopausal group. These findings indicate that the value of s-CTx, as well as urinary CTxs, reflected the increase of bone resorption associated with menopause with a high degree of sensitivity. Patients with vertebral fractures had moderately increased concentrations of bone resorption markers compared to age-matched healthy postmenopausal women (T-score; s-CTx: 0.8, u-alphaCTx: 0.9, u-betaCTx: 0.7), whereas bone resorption markers in hip fracture patients were greatly increased compared to healthy postmenopausal women (T-score; s-CTx: 1.1, u-alphaCTx: 1.3 u-betaCTx: 1.3). The T-scores of u-CTxs against the postmenopausal group in vertebral fracture group and in hip fracture group were not significantly different from those of s-CTx. CONCLUSIONS:
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Authors | K Kawana, M Takahashi, H Hoshino, K Kushida |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 316
Issue 1-2
Pg. 109-15
(Feb 2002)
ISSN: 0009-8981 [Print] Netherlands |
PMID | 11750280
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Biomarkers
- Collagen Type I
- Peptides
- Reagent Kits, Diagnostic
- collagen type I trimeric cross-linked peptide
- Collagen
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Aging
(blood, pathology, urine)
- Biomarkers
(blood, urine)
- Bone Resorption
(blood, urine)
- Case-Control Studies
- Collagen
(blood, urine)
- Collagen Type I
- Enzyme-Linked Immunosorbent Assay
(standards)
- Female
- Hip Fractures
(blood, urine)
- Humans
- Menopause
(blood, urine)
- Middle Aged
- Osteoporosis, Postmenopausal
(blood, urine)
- Peptides
(blood, urine)
- Radioimmunoassay
(standards)
- Reagent Kits, Diagnostic
(standards)
- Spinal Fractures
(blood, urine)
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