Idiotype and anti-idiotype specific T cell responses on transplantation with hybridomas reactive to viral hemagglutinin and human tumor antigen.

Abstract

B cell hybridomas expressing class I and II MHC molecules and producing antibodies directed against hemagglutinin protein of Rinderpest virus and human Mucin-1 have been used as surrogate B cells to study T cell responses against the antigens. The observed CTL and lymphoproliferative response indicates that anti-idiotypic B cells termed Jerne cells stimulate both T helper and T cytotoxic cells by virtue of their ability to present recycled or regurgitated peptido-mimics of antigen to T helper cells through class II MHC and de novo synthesized peptido-mimics of antigens to CTLs. Thus, T cell memory response can be perpetuated by anti-idiotypic Jerne B cells and these findings lend support to the earlier proposed relay hypothesis for perpetuation of immunological memory (IM).

• Authors: Shibani Mitra-Kaushik, M S Shaila, Anjali Karande, Rabindranath Nayak
• Journal: Immunology letters (Immunol Lett) Vol. 80 Issue 2 Pg. 81-7 (Feb 01 2002) ISSN: 0165-2478 [Print] Netherlands
• PMID: 11750038 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies
• Antigens, Neoplasm
• Epitopes
• Hemagglutinins, Viral

Topics

• Animals
• Antibodies (immunology)
• Antigens, Neoplasm (immunology)
• B-Lymphocytes (immunology)
• Cell Transplantation
• Epitopes (immunology)
• Hemagglutinins, Viral (immunology)
• Humans
• Hybridomas (immunology, transplantation)
• Mice
• T-Lymphocytes, Cytotoxic (immunology)
• T-Lymphocytes, Helper-Inducer (immunology)