Role of Fas/FasL genes in azoospermia or oligozoospermia induced by testosterone undecanoate in rhesus monkey.

Abstract

AIM:

To investigate role of apoptosis related genes Fas/FasL in azoospermia or oligozoospermia induced by testosterone undecanoate.

METHODS:

TUNEL was used to detect the apoptotic signal of testicular cells. Immunohistochemistry and Western blot were used to quantitatively or qualitatively analyze the expression of these apoptosis-related proteins.

RESULTS:

After injection of testosterone undecanoate, both the apoptotic signal in germ cells and the expression of Fas/FasL in testis increased correlatively in a time-dependent manner, reaching a maximum level on day 30.

CONCLUSION:

Fas system may initiate and regulate the germ cell apoptosis induced by testosterone undecanoate.

• Authors: X C Zhou, P Wei, Z Y Hu, F Gao, R J Zhou, Y X Liu
• Journal: Acta pharmacologica Sinica (Acta Pharmacol Sin) Vol. 22 Issue 11 Pg. 1028-33 (Nov 2001) ISSN: 1671-4083 [Print] United States
• PMID: 11749796 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contraceptive Agents, Male
• FAS protein, human
• FASLG protein, human
• Fas Ligand Protein
• Membrane Glycoproteins
• Neuropeptides
• Receptors, Tumor Necrosis Factor
• fas Receptor
• Testosterone
• testosterone undecanoate

Topics

• Animals
• Apoptosis (drug effects)
• Contraceptive Agents, Male
• Fas Ligand Protein
• Humans
• Macaca mulatta
• Male
• Membrane Glycoproteins (genetics, physiology)
• Neuropeptides (genetics, physiology)
• Oligospermia (chemically induced, genetics)
• Receptors, Tumor Necrosis Factor
• Spermatozoa (pathology)
• Testosterone (analogs & derivatives)
• fas Receptor