Lymphocytosis induced by polymethacrylic acid. Dose-effect and toxicity.

Abstract

Intravenous polymethacrylic acid (PMAA) significantly increases the number of lymphocytes in the blood of the rat. The relationship between dose-effect and lymphocytosis is linear. The lethal dose in 30 days of PMAA is 120 mg/kg b.w. and the half-lethal dose 80 mg/kg b.w. The treatment with 40 mg/kg b.w. intravenous PMAA gives no toxic histological changes either in the lymph organs, the liver or the kidneys. Thus, PMAA appears to be, at present, a most suitable agent by which to provoke experimentally, migration of the reserve lymphocytes into the blood.

• Authors: S Ormai, M Palkovits
• Journal: Blut (Blut) Vol. 31 Issue 4 Pg. 239-46 (Oct 1975) ISSN: 0006-5242 [Print] Germany
• PMID: 1174718 (Publication Type: Journal Article)

Chemical References

• Acrylic Resins
• Polymethacrylic Acids

Topics

• Acrylic Resins
• Animals
• Dose-Response Relationship, Drug
• Injections, Intravenous
• Kidney (drug effects)
• Lethal Dose 50
• Liver (drug effects)
• Lymphatic System (drug effects)
• Lymphocytosis (chemically induced)
• Male
• Polymethacrylic Acids (toxicity)
• Rats
• Time Factors