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Lymphocytosis induced by polymethacrylic acid. Dose-effect and toxicity.

Abstract
Intravenous polymethacrylic acid (PMAA) significantly increases the number of lymphocytes in the blood of the rat. The relationship between dose-effect and lymphocytosis is linear. The lethal dose in 30 days of PMAA is 120 mg/kg b.w. and the half-lethal dose 80 mg/kg b.w. The treatment with 40 mg/kg b.w. intravenous PMAA gives no toxic histological changes either in the lymph organs, the liver or the kidneys. Thus, PMAA appears to be, at present, a most suitable agent by which to provoke experimentally, migration of the reserve lymphocytes into the blood.
AuthorsS Ormai, M Palkovits
JournalBlut (Blut) Vol. 31 Issue 4 Pg. 239-46 (Oct 1975) ISSN: 0006-5242 [Print] GERMANY, WEST
PMID1174718 (Publication Type: Journal Article)
Chemical References
  • Acrylic Resins
  • Polymethacrylic Acids
Topics
  • Acrylic Resins
  • Animals
  • Dose-Response Relationship, Drug
  • Injections, Intravenous
  • Kidney (drug effects)
  • Lethal Dose 50
  • Liver (drug effects)
  • Lymphatic System (drug effects)
  • Lymphocytosis (chemically induced)
  • Male
  • Polymethacrylic Acids (toxicity)
  • Rats
  • Time Factors

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