Thrombolysis effect with FIIa from Agkistrodon acutus venom in different thrombosis model.

Abstract

AIM:

A fibrinolytic enzyme from Agkistrodon acutus venom, called FIIa, was tested for thrombolytic activity in animals.

METHODS:

Carotid thrombosis model in rats and rabbits and middle cerebral artery (MCA) thrombosis model in rats were used.

RESULTS:

Intravenous administration of FIIa, at a dosage of 0.625 mg/kg, resulted in thrombolysis of carotid thrombi. However, in middle cerebral artery thrombosis, the effective thrombolysis dose was 1.25 mg/kg. When the dosage of FIIa increased, the thrombolytic effect was stronger. Histological examination of kidney, liver, heart, and lung tissue showed no hemorrhage.

CONCLUSION:

It shows that FIIa from Agkistrodon acutus venom is able to solubilize thrombus in vivo without hemorrhage at an effective dose for thrombolysis.

• Authors: J H Chen, X X Liang, P X Qiu, G M Yan
• Journal: Acta pharmacologica Sinica (Acta Pharmacol Sin) Vol. 22 Issue 5 Pg. 420-2 (May 2001) ISSN: 1671-4083 [Print] United States
• PMID: 11743889 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Crotalid Venoms
• Fibrinolytic Agents
• FIIa
• Metalloendopeptidases

Topics

• Agkistrodon
• Animals
• Carotid Arteries
• Crotalid Venoms (adverse effects, chemistry, isolation & purification, therapeutic use)
• Dose-Response Relationship, Drug
• Fibrinolytic Agents (adverse effects, therapeutic use)
• Hemorrhage (chemically induced)
• Male
• Metalloendopeptidases
• Middle Cerebral Artery
• Rabbits
• Rats
• Rats, Wistar
• Thrombosis (drug therapy)