HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Atrophy and apoptosis in ventral prostate of rats induced by 5alpha-reductase inhibitor, epristeride.

AbstractAIM:
To study molecular mechanism of epristeride in the treatment of benign prostatic hyperplasia and discuss the possibility of using prostate acid phosphatase (ACP) as a marker of the atrophy of prostatic gland in vivo.
METHODS:
Morphological changes in cells were observed by light microscope. TdT-mediated dUTP-biotin nick end labeling (TUNEL) technique and agarose gel electrophoresis were performed to detect the nucleosomal DNA fragmentation. The activity of pACP was also assayed.
RESULTS:
Apoptosis occurred in both castration- and epristeride- treatment group. Both the degree and extent of apoptosis are much larger in the group of castration than that of epristeride-treated group. Both epristeride and castration decreased the prostate wet weight and DNA content but increased the prostate DNA concentration. Maximal or near maximal decreases were seen by d 10 in both groups. The activity of ACP was decreased by both castration and epristeride treatment. Changes in the ACP activity during treatment were coincide with other changes such as the prostate wet weight and DNA content.
CONCLUSION:
Apoptosis induced by epristeride was one of mechanisms in the treatment of benign prostatic hyperplasia and the activity of ACP could be used as a marker of prostate atrophy.
AuthorsL H Qian, X L Wang, Z H Tu
JournalActa pharmacologica Sinica (Acta Pharmacol Sin) Vol. 22 Issue 5 Pg. 399-404 (May 2001) ISSN: 1671-4083 [Print] United States
PMID11743885 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • 5-alpha Reductase Inhibitors
  • Androstadienes
  • Biomarkers
  • epristeride
  • Acid Phosphatase
Topics
  • 5-alpha Reductase Inhibitors
  • Acid Phosphatase (metabolism)
  • Androstadienes (adverse effects)
  • Animals
  • Apoptosis
  • Atrophy (chemically induced)
  • Biomarkers (analysis)
  • Male
  • Organ Size (drug effects)
  • Prostatic Hyperplasia (chemically induced, pathology)
  • Rats
  • Rats, Sprague-Dawley

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: