Abstract | AIM: METHODS: Morphological changes in cells were observed by light microscope. TdT-mediated dUTP- biotin nick end labeling (TUNEL) technique and agarose gel electrophoresis were performed to detect the nucleosomal DNA fragmentation. The activity of pACP was also assayed. RESULTS: Apoptosis occurred in both castration- and epristeride- treatment group. Both the degree and extent of apoptosis are much larger in the group of castration than that of epristeride-treated group. Both epristeride and castration decreased the prostate wet weight and DNA content but increased the prostate DNA concentration. Maximal or near maximal decreases were seen by d 10 in both groups. The activity of ACP was decreased by both castration and epristeride treatment. Changes in the ACP activity during treatment were coincide with other changes such as the prostate wet weight and DNA content. CONCLUSION:
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Authors | L H Qian, X L Wang, Z H Tu |
Journal | Acta pharmacologica Sinica
(Acta Pharmacol Sin)
Vol. 22
Issue 5
Pg. 399-404
(May 2001)
ISSN: 1671-4083 [Print] United States |
PMID | 11743885
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- 5-alpha Reductase Inhibitors
- Androstadienes
- Biomarkers
- epristeride
- Acid Phosphatase
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Topics |
- 5-alpha Reductase Inhibitors
- Acid Phosphatase
(metabolism)
- Androstadienes
(adverse effects)
- Animals
- Apoptosis
- Atrophy
(chemically induced)
- Biomarkers
(analysis)
- Male
- Organ Size
(drug effects)
- Prostatic Hyperplasia
(chemically induced, pathology)
- Rats
- Rats, Sprague-Dawley
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