Long-term effects of carvedilol on left ventricular function, remodeling, and expression of cardiac cytokines after large myocardial infarction in the rat.

Abstract

Carvedilol (20 mg/kg, bid) or vehicle was given to rats surviving a myocardial infarction (MI) 24 h (n = 409). In rats with large MI, carvedilol partially preserved left ventricular (LV) function and intrinsic myocardial contractility and reactivity to beta-adrenergic stimulation. Carvedilol led to scar thickening, increased LV hypertrophy, and decreased cardiac fibrosis but did not prevent LV dilatation. Carvedilol reduced cardiac expression of interleukin-1beta but did not prevent cardiac fetal gene re-expression or modify cardiac oxidative stress. Despite these beneficial effects, carvedilol decreased survival (38.8%, versus vehicle, 50.6%) due to excessive early mortality. Thus, post-MI carvedilol has many beneficial effects, however, in this study it increased post-MI mortality, perhaps due to excessive hypotension.

• Authors: Ying Tung Sia, Thomas G Parker, James N Tsoporis, Peter Liu, Albert Adam, Jean L Rouleau
• Journal: Journal of cardiovascular pharmacology (J Cardiovasc Pharmacol) Vol. 39 Issue 1 Pg. 73-87 (Jan 2002) ISSN: 0160-2446 [Print] United States
• PMID: 11743230 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenergic beta-Antagonists
• Carbazoles
• Cytokines
• Propanolamines
• Carvedilol

Topics

• Adrenergic beta-Antagonists (pharmacology)
• Animals
• Carbazoles (pharmacology)
• Carvedilol
• Cytokines (drug effects, metabolism)
• Fibrosis
• Gas Chromatography-Mass Spectrometry
• Hemodynamics (drug effects)
• In Vitro Techniques
• Male
• Myocardial Contraction (drug effects)
• Myocardial Infarction (metabolism, mortality, physiopathology)
• Myocardium (pathology)
• Nuclease Protection Assays
• Oxidative Stress (drug effects)
• Papillary Muscles (drug effects)
• Propanolamines (pharmacology)
• Rats
• Rats, Wistar
• Ventricular Function, Left (drug effects)
• Ventricular Remodeling (drug effects)