Penetration of azidocillin into the secretion and tissues in chronic maxillary sinusitis and tonsillitis.

Abstract

The penetration of azidocillin into the sinus mucosa and secretion as well as into tonsils and adenoids was studied. Altogehter 73 patients were included and they were arranged in four groups according to age, diagnosis and drug dose. The average azidocillin concentration was satisfactory and predictable in all tissues and well over the MIC for most upper respiratory tract pathogens studied. In the maxillary antrum secretion the values were much lower and in many cases under the MIC for hemophilus. This is thought to depend upon the drug's being bound to proteins in the secretions. The clinical results were good in all cases and the contribution of the surgical operation, particularly in providing drainage for the secretion, is obvious.

• Authors: K Jokinen, V Raunio
• Journal: Acta oto-laryngologica (Acta Otolaryngol) 1975 May-Jun Vol. 79 Issue 5-6 Pg. 460-5 ISSN: 0001-6489 [Print] England
• PMID: 1174004 (Publication Type: Journal Article)

Chemical References

• Penicillins
• Penicillin G

Topics

• Adenoids (metabolism)
• Adolescent
• Adult
• Aged
• Child
• Child, Preschool
• Chronic Disease
• Humans
• Maxillary Sinus (metabolism)
• Middle Aged
• Nasal Mucosa (metabolism)
• Palatine Tonsil (metabolism)
• Penicillin G (analogs & derivatives, blood, metabolism, therapeutic use)
• Penicillins (therapeutic use)
• Sinusitis (blood, drug therapy, metabolism)
• Tonsillitis (blood, drug therapy, metabolism)