In patients with malignant
tumors, changes in the blood count and morphological changes in the nucleoli in peripheral-blood lymphocytes were studied during treatment with
Cytembena,
Cyclophosphamide, or combinations of both drugs. After administration of
Cyclophosphamide (400 mg i.v. daily for 10 days, then 100 mg orally daily), the counts of leukocytes, especially of neutrophils, sank (by 40% maximally), and the erythrocyte count and the haemoglobin content in blood sank moderately. In peripheral-blood lymphocytes, the proportion of ring-shaped nucleoli (stimulable to synthesis of
RNA) reversibly sank, and the proportion of micronucleoli (nonstimulable) rose. After administration of
Cytembena (400 mg i.v. daily for 10 days, then 200 mg i.m. at intervals of 2--4 days), neither the leukocyte counts nor the relative percentages of lymphocytic nucleoli signigicantly changed; the mean corpuscular haemoglobin content (MCH) transitorily increased (by 10 percent max.). In the group receiving combined
cytostatics (
Cytembena 400 mg i.v. daily for 10 days, then 200 mg i.m. at intervals of 2--4 days plus
Cyclophosphamide 50 mg orally daily), the erythrocyte count and the haemoglobin content in blood sank moderately. In the population of peripheral-blood lymphocytes in this group, there sank the absolute counts of lymphocytes with ring-shaped nucleoli (by 44% max.) and those with micronucleoli (by 33% max.).